His publications codified the syndromes generated by altered physiologic states of electrolyte imbalance, or endocrine abnormalities, or body fluid deficits. These studies paved the way for the development of nuclear medicine. He was among the first clinicians to inject radioisotopes into laboratory animals, and then into volunteers and patients in order to measure total body water and body composition. Moore developed methods to quantify the concentration of ions in the blood by flame photometry. A perfect anatomical operation could be followed by disastrous complications or death from a low level of circulating sodium chloride or magnesium, or a high level of potassium chloride, or an undetected loss of plasma or water. Surgeons of the day did not understand how to optimize the physiological status of their patients before surgery. Before Moore, surgeons concentrated on improving their craft to effect the local anatomic changes necessary to treat disease, but they remained perplexed by the body’s physiologic response to the trauma of surgery. Throughout the world and reduced suffering and mortality of their patients. These masterpieces changed the thinking of surgeons Ball (1949) and Metabolic Care of the Surgical Patient (1959). At the age of 34 he was Harvard Medical School’s Moseley Professor of Surgery, the youngest chairman of surgery in Harvard’s history.įrancis Moore’s studies, carried out between the physiology laboratory and the patient’s bedside, culminated in two classic books: Metabolic Response to Surgery with M. He would continue to pursue it at the Peter Bent Brigham Hospital, where he arrived in 1948 to become its Surgeon-in-Chief. This new field would become his life’s work.
He became a postgraduate National Research Council fellow in isotope physics and its applications (under Joseph C.
Soon after he had completed his years of surgical training at the Massachusetts General Hospital in Boston and had become its chief resident in surgery in 1942, he began his pioneering work on the metabolic response to surgery. He entered Harvard Medical School and received the M.D. He graduated from Harvard College with the A.B. He was born in Evanston, Illinois, and graduated from the North Shore Country Day School. F RANCIS DANIELS MOORE, one of the world’s great surgeon-scientists, died on November 24, 2001, at the age of 88.
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